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Ponchatoula , Louisiana
April 28, 2011     The Ponchatoula Times
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April 28, 2011

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THE PONCHATOULA TIMES, APRIL 28, 2011, PAGE 8 He alt, Resveratrol loses enthusiasm Red wine fountain ot youth? By DR. RANDOLPH HOWES M.D., PhD (EDITOR'S NOTE: Longtime medical columnist for The Ponchatoula Times, the author is an accomplished surgeon, medical inventor, and Country music recording artist. Dr. Howes grew up on his parents' Ponchatoula strawberry farm. He is a graduate of St. Joseph, Ponchatoula High School, Tulane - two doctorates, followed by a residency at the Johns Hopkins Hospital in plastic surgery. He says he is "re- Sired" now in Kentwood.) Just as other antioxidants have proven to be ineffec- tive, such is the current case for the ever-popular Res- veratrol, the component of red wine that was touted to have anti-aging properties. It has even been hyped as a such a quick fix but recent stud- miraculous "fountain of youth ies have debunked resveratrol's in a pill." Seventy five million unjustified reputation. Baby Boomers are looking for In January of 2011, the New Dr. Howes York Times published an article about GlaxoSmithKline's deci- sion to cancel further clinical trials of resveratrol. In recent years, the evidence linking res- veratrol to anti-aging proteins ("sirtuins") has been seriously challenged. Resveratrol was believed to work by activation of a protein called SIRT1, but at some dos- es, it actually inhibits SIRT1. The original work supporting resveratrol and activation of SIRT1 was found to be an artifact of the scientific fluores- cent dye assay used in the study and this work has been verified by Amgen and confirmed by Pfizer. In August of 2010, the com- pany pushing resveratrol, Sir- tris, also showed that resvera- trol failed to activate SIRT1 in humans. Resveratrol jumped on the headlines after being pushed by Drs. David Sinclair and Christoph Westphal of Harvard Medical School, who formed the Sirtris company and later sold it to GlaxoSmithKline for millions of dollars. Of even more concern, seri- ous side effects have been re- ported, such as kidney failure, nausea, vomiting, diarrhea and dehydration. Thus, some say that resveratrol is neither safe nor effective. A similar scenario has been shown for other anti- oxidants claiming to increase longevity and combat heart dis- ease and cancer. Dr. Nabil S. Kamel and asso- ciates stated in a review article in the December, 2006 issue of the Cleveland Clinic Journal of Medicine, "No single agent has been shown to truly reverse aging or increase longevity in humans. There are not enough data to support the daily use of the antioxidants vitamin A, beta-carotene (the vitamin A precursor), vitamin C, or vita- min E as anti-aging therapies. They had little effect on strokes and heart disease and in fact may even increase overall mor- tality." Actually, documented anti- aging failures abound for vi- tamins A, C and E and for the hormones testosterone, growth hormone and dehydroepi- androsterone (DHEA). To summarize, the scientific results of studies for the claimed miracle results of antioxidant vitamins and touted benefits of hormonal therapy in prevent- ing aging, has not produced a single product or agent, which has been scientifically proven to prevent or reverse the aging process. In the America that I love, we will rely on exercise and a well balanced nutritious diet to promote our overall health and well being. The synthetic sup- plements simply do not work like those contained in fresh fruits and vegetables. Hedda Hopper Award Maratee Fry won the award for the largest and most flamboyant bonnet,. Pretty mamas, pretty daughters at Easter Bonnet Stroll (Times Photo) GRANITE COUNTERTOPS CABINETS SINK VANITY TOPS Quality 3cm Granite $tJll 99 sq. 11--ir in installed 985-893-6616 Fax: 985-893-6615 500 N Highway 190 Suite# D Covington, LA 70433 Q %' Mon.- Sat:9:00 am-5:30 pm I CITY ,WIP,E )'ARP SALE PONCHATOULA'S CITY WIDE YARD SALE APPLICATION June 4th 8am to til Application Deadline:May 15, 2011 CONTACT INFO: NAME PHONE EMAIL REQUIRED INFORMATION TO BE PUBLISHED ON THE MAP: 1) STREET ADDRESS OF SALE SITE 2) BRIEF DESCRIPTION OF SALE ITEMS ( 10-12 WORDS OR LESS) 3) FEE $10.00 PAY TO: PONCHATOULA CHAMBER OF COMMERCE (985-386-2536) QUESTION/COMMENTS CONTACT: BRENDA (1-877-285-5698) or (985-386-5776) ***apps with fees received outside sale boundries will be considered a donation to PCOC ii i i iii i i ii iiiiiii ii '1 FRIED CATFISH DON'S CLASSIC STUFFED Cnsp goen  stps. Served wh HAMBURGER STEAK French fries and hush puppies. $9 - .Seasoned to perfection, stuffed with cheese and topped with smothered onions and gravy $10 h Cajun GUMBO AND SALAD Potatoes. $9 A cup of hot shrimp gumbo with a cool shrimp SEAFOOD SALAD salad. $t0 Boiled Gulf shrimp and crawfish served on top RIBEYE STEAK of a blend of crisp lettuce. $11 THE LAGNIAPPE Filet catfish fried in Chef's own spedal sea- .... TASTE OF THE BAYOU topped with crawfish An exciting array of seafood that,features RED BEANS AND RICE A Louisiana tradition, seasoned just right Served with hush puppies. $6 FRIED GULF SHRIMP AND FRIED CATFISH Gulf shrimp and catfish battered and fried in Dons great tradition of spices. Served with French fries. $10 FRIED GULF SHRIMP Everyone's favorite, battered with fresh French bread crumbs, assuring the finest Louisiana flavors. Served with French fries, $10 crawfish hush puppies. $12, SHRIMP AU GRATIN Tender crabmat and shrimp prepared in our own creamy cheese sauce served with Cajun Potatoes. $10 GRILLED CHICKEN PASTA A creamy and seasoned Alfredo sauce over fettuccini noodles toped with grilled marinated chicken breast. $10 GUMBO AND SALAD A cup of hot shrimp gumbo with a cool shrimp salad: $10 Add a dinner salad or another side " .tour entree. $2 Start with a dozen of our $3 doz